Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

Targeting Breast Cancer Metastasis

Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic effi...

Targeting lemurs against cancer metastasis

Breast cancer is the most frequently diagnosed cancer and the leading cause of mortality in females worldwide. Despite the great improvement in survival rates the last two decades, relapsed disease with metastasis still remains the most poorly understood aspect of cancer pathogenesis [1]. Consequently, there is a growing need to identify so-called new ‘players’ implicated in this process. Lemur...

Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women.

OBJECTIVES Aortic stiffness, determined by the pulse wave velocity (PWV), is an independent marker of cardiovascular risk. PWV is mainly influenced by age-associated alterations of arterial wall structure and blood pressure (BP). To determine the impact of hormone replacement therapy (HRT) on arterial compliance in normotensive, postmenopausal women, we examined the effects of HRT on PWV. MET...

Targeting Neuromimicry in Prostate Cancer Metastasis

Targeting angiogenesis in cancer therapy.

Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. ...